View abstract. Int.J Gynaecol.Obstet. However, the study had only 40 participants, so its findings require further investigation. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Rheum Dis 1988;47:96-104. View abstract. Special Precautions & Warnings: Pregnancy and breast-feeding: Taking evening primrose by mouth is POSSIBLY SAFE during pregnancy. Menendez JA, del Mar Barbacid M, Montero S, et al. Eur J Gastroenterology and Hepatology 1991;3(1):87-90. Joint swelling (inflammation) in people with psoriasis. Kokke KH, Morris JA, and Lawrenson JG. View abstract. Tomczyk, M., Zovko-Koncic, M., and Chrostek, L. Phytotherapy of alcoholism. View abstract. View abstract. Health Technol Assess 2000;4(37):1-191. One person who was taking evening primrose oil and other medications had a seizure during surgery. Gateley, C. A., Maddox, P. R., Pritchard, G. A., Sheridan, W., Harrison, B. J., Pye, J. K., Webster, D. J., Hughes, L. E., and Mansel, R. E. Plasma fatty acid profiles in benign breast disorders. View abstract. View abstract. Horrobin, D. F. Lipids and schizophrenia. 1. She graduated with honors from New York University and completed her clinical internship at the University of Medicine and Dentistry of New Jersey. Mansel RE, Pye JK, and Hughes LE. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 46. View abstract. Arzneimittelforschung. Am.J.Obstet.Gynecol. 2003;139(1):21. Pellegrina, C. D., Padovani, G., Mainente, F., Zoccatelli, G., Bissoli, G., Mosconi, S., Veneri, G., Peruffo, A., Andrighetto, G., Rizzi, C., and Chignola, R. Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis. View abstract. Senapati S, Banerjee S, and Gangopadhyay DN. Acta Chinese Medicine and Pharmacology 1993;21(4):37-38. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(12):714-7, 707. Prostaglandins Leukot Essent Fatty Acids 2002;67:1-12. 44 years experience Pathology. Lets take a look at other precautions to be mindful of when using evening primrose oil. According to the same source, EPO may cause labor abnormalities. Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity. This popular home remedy can interact with common drugs — from aspirin to blood thinners — and cause adverse reactions. View abstract. Evening primrose oil benefits are said to include everything from PMS relief to better cardiovascular health. Chasteberry Tree? 8-12-1995;137(7):169-170. View abstract. View abstract. Liu, L. Z. Wu Q. Liu P. J. Li G. Q. Bensoussan A. Kiat H. Chinese herbal medicines for hypertriglyceridemia. Womens Health Issues 1994;4(3):130-137. Lis-Balchin, M. Parallel placebo-controlled clinical study of a mixture of herbs sold as a remedy for cellulite. Most of the time it happens because the dose is too high. A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). J Am.Acad.Dermatol. Gamma-linolenic acid: A pharmacological nutrient for hypertension? The hypotensive effect of dietary gamma-linolenic acid and associated alterations in tissue fatty acid composition and the Renin-Angiotensin system. Phytother Res. However, other studies using up to 6 grams daily for up to 4 menstrual cycles found no benefit. Some reported side effects include nausea, stomach pain, and headaches [ 107, 37 ]. View abstract. View abstract. Veale DJ, Torley HI, Richards IM, O'Dowd A, Fitzsimons C, Belch JJ, and Sturrock RD. Do any folk remedies or herbals help induce labor? Coskery G, Cowley N Allen R. The effect of dietary supplementation with evening primrose oil on skin surface texture in atopic dermatitis. Menopause. pregnancy, upcoming surgery, etc. Berth-Jones J, Graham-Brown RA. J Perinat.Neonatal Nurs. View abstract. Blommers J, de Lange-De Klerk ES, Kuik DJ, et al. It's also marketed for its ability to relieve the pain and discomfort associated with arthritic disorders, eczema, liver cancer and other ailments. Ann.N.Y.Acad.Sci. Stonemetz, D. A review of the clinical efficacy of evening primrose. View abstract. Kwon HS, Lee JH, Kim GM, Choi EH, Bae JM. View abstract. For example, evening primrose oil should not be used along with Prozac, Zoloft, Celexa and other selective serotonin reuptake inhibitors (SSRIs). Invest Ophthalmol.Vis.Sci 2005;46(12):4474-4479. Horrobin DF. Aging (Milano.) Prostaglandins Leukot Essent Fatty Acids 1989;37(3):145-147. View abstract. Aust N Z J Surg 1999;69:492-4.. View abstract. A controlled trial of evening primrose oil (Efamol) in cyclic premenstrual mastalgia. 2008;57(8):542-544. Relationship between plasma essential fatty acid changes and clinical response. The etiopathogenesis of premenstrual syndrome as a consequence of altered blood rheology: a new hypothesis. 2002;79(3):195-207. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. (Accessed 2 June 2003). Although not all side effects are known, evening primrose is thought to be likely safe for most people when used for up to a year. 8-8-2005;226(1):17-25. A double-blind controlled trial of gammalinolenic acid (GLA) in the management of pre-menstrual gastrointestinal symptoms. Br.J Surg. Br J Dermatol 1987;117:11-9. Childbirth. View abstract. Field, E. J. and Joyce, G. Effect of prolonged ingestion of gamma-linolenate by MS patients. Reden, J., El-Hifnawi, D., Zahnert, T., and Hummel, T. The effect of a herbal combination of primrose, gentian root, vervain, elder flowers, and sorrel on olfactory function in patients with a sinonasal olfactory dysfunction. Low, Dog T. Menopause: a review of botanical dietary supplements. Horrobin, D. F. and Stewart, C. Evening primrose oil and atopic eczema. View abstract. Engler MM, Engler MB, Erickson SK, Paul SM. View abstract. Canning S, Waterman M Dye L. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy. 1999. Arzneimittelforschung 2005;55(11):669-676. Research evaluating evening primrose for improving childbirth shows conflicting results. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. View abstract. Be sure to tell your doctor what natural products you are taking before having surgery. View abstract. Dove D, Johnson P. Oral evening primrose oil: its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women (abstract). Did you or will you purchase this product in-store or online? Guenther, L. and Wexler, D. Efamol in the treatment of atopic dermatitis. Stordy BJ. BMJ 1994;309:824-825. Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. View abstract. View abstract. Lancet 1995;345(8963):1463-1468. Abnormalities in plasma essential fatty acid levels in women with premenstrual syndrome and nonmalignant breast disease. Journal of Holistic Medicine. J Reprod.Med 1983;28(7):465-468. View abstract. Prostaglandins Leukot Essent Fatty Acids 1994;51:311-6. View abstract. View abstract. 43 years experience Pathology. Med Cutan.Ibero.Lat.Am 1986;14(2):133-137. View abstract. Evening primrose oil as a treatment of premenstrual syndrome. View abstract. 2012;3, Centre for Reviews and Dissemination. Clin Exp Dermatol. View abstract. Side effects, drug interactions, dosage, storage, and safety information should be reviewed prior to taking this supplement. Although these findings are promising, more research is needed to validate them. Oliwiecki S and Burton JL. Gimenes, O. M., da Silva, M. J., and Benko, M. A. J Reprod.Med 1997;42(10):637-646. HeadacheDon't take evening primrose if you have a bleeding disorder. View abstract. Manchester, England, April 1991. pg 89-96. View abstract. A 20-year-old male asked: does taking evening primrose oil capsulesdaily cause side effects like reduced testosterone levels? 2016;2(2):83-88. For example, an October 2016 research paper published in Pharmacological Reviews assessed several herbal supplements and their role in women's health. 1995;6(4):209-212. Skogh, M. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma- linolenic acids). Lack of effect of evening primrose oil on autonomic function tests after 12 months of treatment. Woltil, H. A., van Beusekom, C. M., Schaafsma, A., Okken, A., and Muskiet, F. A. 1987;62 Suppl 1:100-103. Bayles, B. and Usatine, R. Evening primrose oil. Menendez JA, Colomer R, Lupu R. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-Linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. Vitamin D and evening primrose oil administration improve glycemia and lipid profiles in women with gestational diabetes. View abstract. Hot flashes experienced by women going through the menopause have a number of non-hormonal treatment options, but, according to the evidence, evening primrose oil does not have an effect. Br J Surg. Schizophr.Res 4-10-1998;30(3):193-208. Drug companies' evidence to justify advertising. Morse PF, Horrobin DF, Manku MS, et al. Cortisone in ulcerative colitis. Am J Clin Nutr 2000;71:386S-392S. 2003;16(1):47-57. 2010;24(3):238-245. Makrides M, Neumann M, Simmer K, Pater J, and Gibson R. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? 1994;28(7-8):973. Greaves, M. W. and Corbett, M. F. Treatment of atopic eczema with evening primrose oil. Am J Med 12-19-2005;118 Suppl 12B:98-108. Girman, A., Lee, R., and Kligler, B. In most cases, evening primrose oil side effects are linked to excess use, impurities in the oil and improper usage. Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. Evening primrose oil (EPO) has been used as a PMS remedy for centuries. Hemorrhagic stroke and allergic reactions, warns the European medicines Agency brzeski M, Vasiljevic D, al... Obstet.Gynaecol.Can 2006 ; 195 ( 6 Suppl 1 ) side effects of evening primrose oil S30 Metab Care 1999 60. 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